SEOUL NATIONAL UNIVERSITY
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이철환 Lee, Chul-Hwan사진

Epigenetics and Molecular Pharmacology Laboratory

(https://chulhwanlab.com)

We discover the mechanisms of gene regulation focusing on enzyme kinetics and its implication in human diseases.

 

Education

2005 – 2010         Ph.D., Department of Biological Sciences, KAIST
2001 – 2005         B.S., Department of Biological Sciences, KAIST
 

Professional Experiences
2020 – Present    Associate Professor, Seoul National University College of Medicine
2018 – 2020       HHMI Research Specialist, HHMI / NYU School of Medicine
2015 – 2018       HHMI Postdoctoral Fellow, HHMI / NYU School of Medicine
2011 – 2015       Postdoctoral Fellow, University of Texas, Southwestern Medical Center

 

Selected Publications

Lee CH*, Yu JR*, Granat J*, Saldaña-Meyer R, Andrade J, LeRoy G, Jin Y, Lund P, Stafford JM, Garcia BA, Ueberheide B, Reinberg D (2019) Automethylation of PRC2 promotes H3K27 methylation and is impaired in H3K27M pediatric glioma. Genes & Development [IF= 9.527] 33(19-20),1428-1440.

Yu JR*, Lee CH*, Oksuz O*, Stafford JM, Reinberg D (2019) PRC2 is high maintenance. Genes & Development [IF= 9.527] 33(15-16), 903-935.

Stafford JM*, Lee CH*, Voigt P, Descostes N, Saldaña-Meyer R, Yu JR, Leroy G, Oksuz O, Chapman JR, Suarez F, Modrek AS, Bayin NS, Placantonakis DG, Karajannis MA, Snuderl M, Ueberheide B, Reinberg D (2018) Multiple modes of PRC2 inhibition elicit global chromatin alterations in H3K27M pediatric glioma. Science Advances [IF= 13.116] 4(10), eaau5935.

Lee CH*, Holder M*, Grau D, Saldaña-Meyer R, Yu JR, Ganai RA, Zhang J, Wang M, LeRoy G, Dobenecker MW, Reinberg D, Armache KJ(2018) Distinct stimulatory mechanisms regulate the catalytic activity of Polycomb Repressive Complex 2 (PRC2). Molecular Cell [IF= 15.584] 70(3), 435-448.

Lee CH*, Yu JR*, Kumar S, Jin Y, LeRoy G, Bhanu N, Kaneko S, Garcia BA, Hamilton AD, Reinberg D (2018) Allosteric activation dictates PRC2 activity independent of its recruitment to chromatin. Molecular Cell [IF= 15.584] 70(3), 422-434.

Lee CH, Wu, J, Li, B (2013) Chromatin remodelers fine-tune H3K36me-directed deacetylation of neighbor nucleosomes by Rpd3S. Molecular Cell [IF= 15.584] 52(2), 255-263.

 

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