SEOUL NATIONAL UNIVERSITY
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이창한 Lee, Chang Han사진

The Lee Lab at SNU MEDICINE

Antibody Therapeutics and Cancer Immunology

(https://www.theleelab-antibody.com/)

          EDUCATION

Institution

Degree

Year

Field of Study

Ajou University, South Korea

B.S.

2007

Chemical and biological engineering

Ajou University, South Korea

Ph.D.

2013

Molecular Science and Technology

(Advisor: Prof. Yong-Sung Kim

POSITIONS AND EMPLOYMENT

Institution

Years

Position

Seoul National University

2020-Present

Assistant Professor

The University of Texas at Austin, USA

2018-2020

Research associate in Department of Chemical Engineering (Advisor: Prof. George Georgiou)

The University of Texas at Austin, USA

2013-2018

Postdoctoral Fellow in Department of Chemical Engineering (Advisor: Prof. George Georgiou)

EXPERIENCE

Years

Project

2010

Participated in school-enterprise research project about antibody binding kinetics and stoichiometry (filed for IND process)

2018

Consulting in Agenus Inc.

REPRESENTATIVE PUBLICATIONS

  1. Chang-Han Lee†, Tae Hyun Kang†, Ophélie Godon, Makiko Watanabe, George Delidakis, Caitlin M. Gillis, Delphine Sterlin, David Hardy, Michel Cogné, Lynn E. Macdonald, Andrew. J. Murphy, Naxin Tu, Jiwon Lee, Jonathan R. McDaniel, Emily Makowski, Peter Tessier, Aaron S. Meyer, Pierre Bruhns*, and George Georgiou* An Engineered Human Fc Domain that Behaves like a pH-Toggle Switch for Ultra-Long Circulation Persistence. Nature Communications 2019 Nov 6 10:5031 († equally contributed).

  2. Tae Hyun Kang†, Chang-Han Lee†, George Delidakis, Jiwon Jung, Odile Richard-Le Goff, Jiwon Lee, Jin Eyun Kim, Wissam Charab, Pierre Bruhns, and George Georgiou* (2019) An Engineered Human Fc variant with Exquisite Selectivity for FcγRIIIaV158 Reveals that Ligation of FcγRIIIa Mediates Potent Antibody Dependent Cellular Phagocytosis with GM-CSF-differentiated Macrophages. Frontiers in Immunology 2019 Mar. 27. 10: 562 († equally contributed).

  3. Chang-Han Lee, Gabrielle Romain, Wupeng Yan, Makiko Watanabe, Wissam Charab, Biliana Todorova, Jiwon Lee, Kendra Triplett, Moses Donkor, Oana I. Lungu, Anja Lux, Nicholas Marshall, Odile RICHARD-LE GOFF, Tae Hyun Kang, Hidetaka Tanno, George Delidakis, Corrine Alford, Ronald P. Taylor, Falk Nimmerjahn, Navin Varadarajan, Pierre Bruhns, Yan Jessie Zhang and George Georgiou* (2017) IgG Fc domains that bind C1q but not effector Fcγ receptors delineate the importance of complement-mediated effector function. Nature Immunology 2017 Aug; 18(8): 889-898.

    * This article was highlighted by Cees E van der Poel & Michael C Carroll “Untangling Fc and complement receptors to kill tumors”. APS (Advanced Photon Source) and ALS (Advanced Light Source) were highlighted it too.

    * This article was recommended by Cancer Immunology Research Journal, “What we’re reading”

  4. Chang-Han Lee, Kyung-Jin Park, Sang Jick Kim, Ohsuk Kwon, Ki Jun Jeong, Ayeung Kim, and Yong-Sung Kim* (2011) Generation of bivalent and bispecific Kringle single domains by loop grafting as potent agonists against death receptor 4 and 5. Journal of Molecular Biology. 2011 August 5; 411 (1):201-219.

  5. Chang-Han Lee, Kyung-Jin Park, Eun-Sil Sung, Aeyung Kim, Ji-Da Choi, Jeong-Sun Kim, Soo-Hyun Kim, Myung-Hee Kwon, Yong-Sung Kim* (2010) Engineering of a human kringle domain into agonistic and antagonistic binding proteins functioning in vitro and in vivo. Proceedings of the National Academy of Sciences of the United States of America. 2010 May 11; 107:9567-9571.

    PATENTS

Registered Patents:

  1. Yong-Sung Kim, Myung-Hee Kwon, Chang-Han Lee, Protein Scaffold Library Based on Kringle Domain Structure and Uses Thereof. US 8,492,343 7 August 2009.

Applied Patent:

  1. George Georgiou, Chang-han Lee,

  2. George Georgiou, Chang-han Lee, Aug 2016

  3. George Georgiou, Chang-han Lee, Tae Hyun Kang, Engineered antibody Fc variants for enhanced serum half life. PCT/US2019/0048078 11 Aug 2018

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